Cyclization of Nitroacetamide Derivatives with a Tethered Phenyl Ring in Triflic Acid
| العنوان: | Cyclization of Nitroacetamide Derivatives with a Tethered Phenyl Ring in Triflic Acid |
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| المؤلفون: | Jerome Marrot, Jean-Marie Coustard, Bamba Fanté, Sorho Siaka, Yaya Soro |
| المصدر: | Synlett. 25:969-974 |
| بيانات النشر: | Georg Thieme Verlag KG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | chemistry.chemical_compound, chemistry, Bicyclic molecule, Organic Chemistry, polycyclic compounds, Cationic polymerization, Intramolecular cyclization, Protonation, Ring (chemistry), Triflic acid, Medicinal chemistry |
| الوصف: | N-(3-Hydroxypropyl)-2-nitro-N-(ω-phenylalkyl)acetami-des underwent intramolecular cyclization in triflic acid to afford the corresponding hydroxyimino six- to nine-membered benzofused lactams. The six-membered derivative slowly transformed into 2-(3-hydroxypropyl)isoquinolin-3-one. NMR spectroscopic analysis in situ provided information on the cationic species involved in the reaction, permitting a mechanism to be postulated. This reaction provides a novel and simple route to benzofused lactams. |
| تدمد: | 1437-2096 0936-5214 |
| DOI: | 10.1055/s-0033-1340960 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8440181c13a0f56d38ae7ca38aa63523 https://doi.org/10.1055/s-0033-1340960 |
| رقم الانضمام: | edsair.doi...........8440181c13a0f56d38ae7ca38aa63523 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14372096 09365214 |
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| DOI: | 10.1055/s-0033-1340960 |