New ferrocenyl guanidines as potent antioxidants, protein kinase inhibitors and cytotoxic agents against human leukemia THP-1 cell line
| العنوان: | New ferrocenyl guanidines as potent antioxidants, protein kinase inhibitors and cytotoxic agents against human leukemia THP-1 cell line |
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| المؤلفون: | A. Ali Altaf, Saira Tabassum, Muhammad Zia, Rukhsana Gul, Amin Badshah |
| المصدر: | Russian Journal of General Chemistry. 87:2684-2689 |
| بيانات النشر: | Pleiades Publishing Ltd, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Antioxidant, biology, 010405 organic chemistry, DPPH, medicine.medical_treatment, Brine shrimp, General Chemistry, 010402 general chemistry, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Biochemistry, chemistry, Cell culture, medicine, THP1 cell line, Cytotoxicity, Protein kinase A, IC50 |
| الوصف: | Six new ferrocenyl guanidines were synthesized and characterized by elemental analysis, FT-IR and 1H and 13C NMR. Compounds 1–6 were screened for antioxidant, protein kinase inhibition, lethality of brine shrimp, and cytotoxicity against the human leukemia THP-1 cell line. The compounds demonstrated moderate to significant activities. Antioxidant activity of the synthesized compounds was evaluated by DPPH % inhibition with IC50 values. All compounds 1–6 showed notable antioxidant activity with DPPH having IC50 values between 23.2–15.1 and noteworthy brine shrimp lethality. Compound 6 demonstrated the highest cytotoxicity against brine shrimps with LC50 of 9.09 μg/mL. Protein kinase inhibition activity showed significant hyphea formation inhibition at 100 μg/disc with 10 to 13 mm clear zone of inhibition for the compounds 2–6. The compounds were screened for in vitro cytotoxicity using human leukemia cell line (THP-1 ATCC#TIB-202). Among all compounds, the most significant activity was demonstrated by compounds 6 and 5 with IC50 of 3.88 and 5.59 μg/mL which was comparable with the standard 5-flourouracil and vincristine drugs. |
| تدمد: | 1608-3350 1070-3632 |
| DOI: | 10.1134/s1070363217110251 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::81a20311a7a7cc0ee6b583706325368c https://doi.org/10.1134/s1070363217110251 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........81a20311a7a7cc0ee6b583706325368c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16083350 10703632 |
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| DOI: | 10.1134/s1070363217110251 |