Human gamma delta T cell subset-proliferative response to malarial antigen in vitro depends on CD4+ T cells or cytokines that signal through components of the IL-2R
| العنوان: | Human gamma delta T cell subset-proliferative response to malarial antigen in vitro depends on CD4+ T cells or cytokines that signal through components of the IL-2R |
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| المؤلفون: | M M Elloso, H C van der Heyde, A Troutt, D D Manning, W P Weidanz |
| المصدر: | The Journal of Immunology. 157:2096-2102 |
| بيانات النشر: | The American Association of Immunologists, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | We examined the cellular and molecular basis of the proliferative response of human gamma delta T cells in cultures of PBMC stimulated with blood-stage Plasmodium falciparum malarial Ag. Flow cytometry revealed that maximal gamma delta T cell proliferation occurs after maximal CD4+ alpha beta T cell proliferation. Depletion of CD4+ T cells from PBMC before stimulation with malarial Ag markedly reduces the number of proliferating gamma delta T cells, which suggests that CD4+ T cells function in providing help to gamma delta T cells to respond to this parasite Ag. Removal of gamma delta T cells, however, did not alter the expansion of the CD4+ T cell subset. The addition of exogenous IL-2, IL-4, or IL-15 restored the capacity of gamma delta T cells to proliferate in Ag-stimulated cultures of PBMC depleted of CD4+ T cells. mAbs specific for the alpha- and beta-subunits of the IL-2 receptor inhibit the gamma delta T cell subset expansion in cultures stimulated with malarial Ag. Taken together, these findings suggest that the proliferation of gamma delta T cells in response to malarial Ag is dependent on the presence of CD4+ alpha beta T cells, but the requirement for CD4+ alpha beta T cells can be met by cytokines that use the IL-2R. |
| تدمد: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.157.5.2096 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7d2b0056d6d0246b0665a515fbd0ca0c https://doi.org/10.4049/jimmunol.157.5.2096 |
| رقم الانضمام: | edsair.doi...........7d2b0056d6d0246b0665a515fbd0ca0c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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| DOI: | 10.4049/jimmunol.157.5.2096 |