Survival of patients with colorectal cancer (CRC) with low expression of homologous recombination proficient (HRP) genes
| العنوان: | Survival of patients with colorectal cancer (CRC) with low expression of homologous recombination proficient (HRP) genes |
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| المؤلفون: | Daniel Walden, Sachin Deshmukh, Felipe Batalini, Binbin Zheng-Lin, Sharon Wu, Joanne Xiu, Emil Lou, Daniel H. Ahn, Christina Wu, Sanjay Goel, Anthony Frank Shields, David Spetzler, Matthew James Oberley, Wolfgang Michael Korn, Tanios S. Bekaii-Saab |
| المصدر: | Journal of Clinical Oncology. 41:225-225 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cancer Research, Oncology |
| الوصف: | 225 Background: HR deficient (HRD) CRC has improved outcomes following exposure to DNA damaging agent (DDA) (irinotecan, IR; oxaliplatin, OX) compared to HRP CRC. Low expression of wild type (WT) BRCA1 mRNA is associated with prolonged OS in ovarian cancer; however, this finding has not been investigated in CRC or outside of BRCA. Here, we examine the effect of low expression of HR genes in HRP CRC on post-DDA survival. Methods: 12,860 CRC samples were analyzed by NGS (592, NextSeq; WES, NovaSeq) and WTS (NovaSeq) at Caris Life Sciences (Phoenix, AZ). Samples were classified by RNA expression percentiles. Real world OS was extracted from insurance claims and calculated using Kaplan-Meier estimates for molecularly defined cohorts from first of OX or IR to last contact. Results: Post-IR survival was prolonged with low expression of ATM, CHEK2 and PALB2 in WT ATM, PALB2, and CHEK2 WT CRC, respectively (bottom vs. top 10%, bottom vs. top 25%; p |
| تدمد: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2023.41.4_suppl.225 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7b810dd26dac371ecfefe5e23011eabe https://doi.org/10.1200/jco.2023.41.4_suppl.225 |
| رقم الانضمام: | edsair.doi...........7b810dd26dac371ecfefe5e23011eabe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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| DOI: | 10.1200/jco.2023.41.4_suppl.225 |