ChemInform Abstract: Spirolactones of Tyrosine: Synthesis and Reaction with Nucleophiles
| العنوان: | ChemInform Abstract: Spirolactones of Tyrosine: Synthesis and Reaction with Nucleophiles |
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| المؤلفون: | A. Ziogas, Medhat El-Mobayed, Anton Rieker, Antun Hutinec |
| المصدر: | ChemInform. 29 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | chemistry.chemical_classification, chemistry.chemical_compound, Dipeptide, chemistry, Nucleophile, Stereochemistry, Side chain, Moiety, General Medicine, Phenols, Tyrosine synthesis, Tyrosine, Amino acid |
| الوصف: | Several quinonoidal spirolactones (1-oxaspiro[4,5]deca-6,9-diene-2,8-diones) 12 have been synthesized chemically or electrochemically by oxidation of the corresponding tyrosine phenols 3. The spirolactones are of considerable value in peptide chemistry, because they react as active esters with amino acid esters to give dipeptides. In the latter, the side chain of the tyrosine moiety is present as a quinol (4-hydroxycyclohexa-2,5-dien-1-one) system, which can be reduced to the genuine tyrosyl dipeptide. Unsubstituted spirolactones also react as active esters but give dipeptides only in modest yields. |
| تدمد: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.199848212 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::789abe81e03a2ddd87887f3fd5dbdfd2 https://doi.org/10.1002/chin.199848212 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........789abe81e03a2ddd87887f3fd5dbdfd2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222667 09317597 |
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| DOI: | 10.1002/chin.199848212 |