B cells in autoimmune and neurodegenerative central nervous system diseases
| العنوان: | B cells in autoimmune and neurodegenerative central nervous system diseases |
|---|---|
| المؤلفون: | Joseph J. Sabatino, Anne-Katrin Pröbstel, Scott S. Zamvil |
| المصدر: | Nature Reviews Neuroscience. 20:728-745 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, biology, business.industry, General Neuroscience, Multiple sclerosis, Antigen presentation, Autoantibody, Acquired immune system, medicine.disease, Proinflammatory cytokine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Immune system, Immunopathology, Immunology, biology.protein, Medicine, Antibody, business, 030217 neurology & neurosurgery |
| الوصف: | B cells are essential components of the adaptive immune system and have important roles in the pathogenesis of several central nervous system (CNS) diseases. Besides producing antibodies, B cells perform other functions, including antigen presentation to T cells, production of proinflammatory cytokines and secretion of anti-inflammatory cytokines that limit immune responses. B cells can contribute to CNS disease either through their actions in the periphery (meaning that they have an 'outside-in' effect on CNS immunopathology) or following their compartmentalization within the CNS. The success of B cell-depleting therapy in patients with multiple sclerosis and CNS diseases with an autoantibody component, such as neuromyelitis optica spectrum disorder and autoimmune encephalitides, has underscored the role of B cells in both cellular and humoral-mediated CNS conditions. Emerging evidence suggests B cells also contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer disease and Parkinson disease. Advancing our understanding of the role of B cells in neuroinflammatory and neurodegenerative diseases could lead to novel therapeutic approaches. |
| تدمد: | 1471-0048 1471-003X |
| DOI: | 10.1038/s41583-019-0233-2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::788e0b60088725d822247e2e302b9fd8 https://doi.org/10.1038/s41583-019-0233-2 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........788e0b60088725d822247e2e302b9fd8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14710048 1471003X |
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| DOI: | 10.1038/s41583-019-0233-2 |