Correction: Learning from each other: ABC transporter regulation by protein phosphorylation in plant and mammalian systems
| العنوان: | Correction: Learning from each other: ABC transporter regulation by protein phosphorylation in plant and mammalian systems |
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| المؤلفون: | Markus Geisler, Christophe V. F. P. Laurent, Bibek Aryal |
| المصدر: | Biochemical Society Transactions. 44:663-673 |
| بيانات النشر: | Portland Press Ltd., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, biology, ATP-binding cassette transporter, Transporter, biology.organism_classification, Biochemistry, Cystic fibrosis transmembrane conductance regulator, 03 medical and health sciences, 030104 developmental biology, Heat shock protein, Arabidopsis, biology.protein, Phosphorylation, Protein phosphorylation, ATP-binding domain of ABC transporters |
| الوصف: | The ABC (ATP-binding cassette) transporter family in higher plants is highly expanded compared with those of mammalians. Moreover, some members of the plant ABCB subfamily display very high substrate specificity compared with their mammalian counterparts that are often associated with multidrug resistance (MDR) phenomena. In this review we highlight prominent functions of plant and mammalian ABC transporters and summarize our knowledge on their post-transcriptional regulation with a focus on protein phosphorylation. A deeper comparison of regulatory events of human cystic fibrosis transmembrane conductance regulator (CFTR) and ABCB1 from the model plant Arabidopsis reveals a surprisingly high degree of similarity. Both physically interact with orthologues of the FK506-binding proteins (FKBPs) that chaperon both transporters to the plasma membrane in an action that seems to involve Hsp90. Further both transporters are phosphorylated at regulatory domains that connect both nucleotide-binding folds. Taken together it appears that ABC transporters exhibit an evolutionary conserved but complex regulation by protein phosphorylation, which apparently is, at least in some cases, tightly connected with protein–protein interactions (PPI). |
| تدمد: | 1470-8752 0300-5127 |
| DOI: | 10.1042/bst20150128_2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7749114297076d8e8caf5a4859faed56 https://doi.org/10.1042/bst20150128_2 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........7749114297076d8e8caf5a4859faed56 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708752 03005127 |
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| DOI: | 10.1042/bst20150128_2 |