Solvent controlled divergent syntheses of polysubstituted pyrroles and pyrrolo[2,3-b]-1,4-thiazines

التفاصيل البيبلوغرافية
العنوان: Solvent controlled divergent syntheses of polysubstituted pyrroles and pyrrolo[2,3-b]-1,4-thiazines
المؤلفون: Mei-Fang Liu, Ying Cheng, Yang-Guang Ma, Zhi-Mei Kang, Jiang-Hua Peng
المصدر: Tetrahedron. 64:7362-7368
بيانات النشر: Elsevier BV, 2008.
سنة النشر: 2008
مصطلحات موضوعية: Solvent, Ethyl propiolate, chemistry.chemical_compound, chemistry, Organic Chemistry, Drug Discovery, Butanone, Benzene, Ring (chemistry), Biochemistry, Medicinal chemistry, Cycloaddition, Pyrrole
الوصف: The reaction of 2-imidazolyl carbene-derived 2-arylthiocarbamoyl imidazolium salts with ethyl propiolate proceeded via the solvent dependent tandem [3+2] cycloaddition and subsequent ring transformation processes. While the reaction in butanone yielded 3-amino-2-vinylthiopyrroles as the major products, use of benzene as the solvent led to the predominant formation of pyrrolo[2,3-b][1,4]thiazines. This work disclosed a unique ring transformation of imidazoline-spiro-pyrrolines to pyrrolo[2,3-b][1,4]thiazines, which provides a simple route to both multifunctional pyrroles and pyrrolo[2,3-b][1,4]thiazines that are otherwise difficult to synthesize.
تدمد: 0040-4020
DOI: 10.1016/j.tet.2008.05.044
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7642450f53ed8276d3890d2de7b64333
https://doi.org/10.1016/j.tet.2008.05.044
Rights: CLOSED
رقم الانضمام: edsair.doi...........7642450f53ed8276d3890d2de7b64333
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00404020
DOI:10.1016/j.tet.2008.05.044