A multicenter retrospective cohort study evaluating the clinical significance of CA125 in later line of patients with metastatic colorectal cancer
| العنوان: | A multicenter retrospective cohort study evaluating the clinical significance of CA125 in later line of patients with metastatic colorectal cancer |
|---|---|
| المؤلفون: | Ken Ito, Takayuki Ando, Akira Ueda, Iori Motoo, Yosuke Kito, Atsushi Ishiguro, Kazunari Tanaka, Ayumu Hosokawa, Koji Nakashima, Toshiki Wakabayashi, Osamu Muto, Masayoshi Dazai, Taichi Yoshida, Takahiro Yamamura, Kazuaki Harada, Yasuyuki Kawamoto, Naoya Sakamoto, Yoshito Komatsu, Satoshi Yuki |
| المصدر: | Journal of Clinical Oncology. 41:253-253 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cancer Research, Oncology |
| الوصف: | 253 Background: The peritoneal dissemination is one of the metastatic forms of gastrointestinal cancer and has a poor prognosis. It has been reported that the presence of CA125 in mesothelial cells lining the peritoneum is involved in the elevation of CA125 due to peritoneal dissemination and inflammation of cancerous ascites, and CA125 may be a useful predictor of peritoneal dissemination in gastrointestinal cancer. It has also been reported that CA125 correlates with ascites volume and prognosis. However, there are no reports evaluating the clinical significance of CA125 in the later line of metastatic colorectal cancer (mCRC). Therefore, we conducted a multicenter retrospective study. Methods: We retrospectively analyzed the clinical data of 121 patients who received trifluridine/tipiracil (FTD/TPI) or Regorafenib from January 2012 to May 2018 in 10 centers and had the result of serum CA125 just before the treatment. Patients who had received either FTD/TPI or Regorafenib were excluded. In this study, the levels of ascites were classified as follows: "none" as undetectable by computed tomography scanning, "mild" as confined to the pelvic cavity or upper abdomen, "severe" as continuous from the pelvic cavity to the upper abdomen, and "moderate" as between "mild" and "severe". RECIST ver.1.1 was used for analysis of tumor response. Survival analyses were performed with Kaplan-Meier method, log-rank test and Cox proportional hazards model. Results: There were 75 patients in the baseline CA125 normal group (group N) and 46 patients in the high group (group H). ECOG PS tended to be worse in group H than in group N (ECOG PS (0/1/2) 26/43/6 and 9/28/9 in N and H groups, p=0.076). There were significantly more patients with ascites in group H than in group N (Yes/No 7/68 and 26/20 in N and H groups, p |
| تدمد: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2023.41.4_suppl.253 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7510f6d9191e4c842647de93cad2cd22 https://doi.org/10.1200/jco.2023.41.4_suppl.253 |
| رقم الانضمام: | edsair.doi...........7510f6d9191e4c842647de93cad2cd22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
|---|---|
| DOI: | 10.1200/jco.2023.41.4_suppl.253 |