Differential Expression of lincRNA-ROR Spliced Transcript Variants in Breast Cancer
| العنوان: | Differential Expression of lincRNA-ROR Spliced Transcript Variants in Breast Cancer |
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| المؤلفون: | Mozhgan Saadat Akhtar, Akram Gholipour, Mahrokh Bagheri Moghaddam, Maziar Oveisee, Seyed Javad Mowla, Mahshid Malakootian |
| المصدر: | Iranian Journal of Public Health. |
| بيانات النشر: | Knowledge E DMCC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Public Health, Environmental and Occupational Health |
| الوصف: | Background: We investigated the expression pattern of a human stem cell-specific, large intergenic noncoding RNA (lincRNA) regulator of reprogramming (lincRNA-ROR) and its spliced transcript variants in breast tumors. Breast cancer is the leading cause of cancer mortality in women; therefore, finding a reliable diagnostic tumor marker, based on the molecular profile of tumor cells, is warranted. Methods: qRT-PCR was used to investigate the expression alteration of a specific stem cell-related lincRNA and its spliced transcript variants in breast tumors which provided by the Iran National Tumor Bank (2014-2016). Suitability of lincRNA-ROR and expression alterations of its spliced transcript variants as breast tumor biomarkers were examined by ROC curve analysis. Results: Expression was significantly upregulated in lincRNA-ROR variants 1 (NR-048536) and 4 (AB844432) and downregulated in variant 3 (AB844431), with expression levels failing to distinguish between breast tumor types, grades, and malignancy stages. Whereas ROC curve analysis gave good scores to the expressions of variants 1 (AUC=0.7675, P=0.003) and 3 (AUC=0.9383, P=0.00173), suggesting their suitability as potential breast tumor biomarkers, it gave an AUC score of 0.6033 for lincRNA-ROR spliced variant 4 (P=0.4118), denoting its unsuitability as a breast cancer biomarker. Conclusion: Aberrant expressions of lincRNA-ROR spliced transcript variants could serve as reliable biomarkers with potential usefulness in breast cancer diagnosis. However, further research should elucidate the role and tissue expression of lincRNA-ROR spliced transcript variants in various cancers. |
| تدمد: | 2251-6093 2251-6085 |
| DOI: | 10.18502/ijph.v52i2.11896 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::74e3c7a8942f76ac2d082da0ae062120 https://doi.org/10.18502/ijph.v52i2.11896 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........74e3c7a8942f76ac2d082da0ae062120 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22516093 22516085 |
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| DOI: | 10.18502/ijph.v52i2.11896 |