Plasma levels of 15d-PGJ2are not altered in multiple sclerosis
| العنوان: | Plasma levels of 15d-PGJ2are not altered in multiple sclerosis |
|---|---|
| المؤلفون: | José Antonio del Río, Jesús M. Pradillo, Manuel Comabella, Eva Julià, María A. Moro, M. Fernández, Jaume Sastre-Garriga, Xavier Montalban, Ignacio Lizasoain |
| المصدر: | European Journal of Neurology. 16:1197-1201 |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Agonist, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.drug_class, Multiple sclerosis, Plasma levels, Disease, medicine.disease, Prostaglandin J2, Endocrinology, Cerebrospinal fluid, Neurology, Internal medicine, Immunoassay, Medicine, 15d pgj2, Neurology (clinical), business |
| الوصف: | Background: The 15-deoxi delta prostaglandin J2 (15d-PGJ2) is a peroxisome proliferator-activated receptor-gamma agonist with potent anti-inflammatory properties. It has been suggested that 15d-PGJ2 may modulate multiple sclerosis (MS). Methods: Here, we investigated the plasma levels of 15d-PGJ2 by enzyme-linked immunoassay in 28 healthy controls and 140 MS patients [30 patients with primary-progressive MS, 28 patients with secondary-progressive MS, and 82 patients with relapsing-remitting MS (28 patients during clinical remission, 25 patients during relapse, and 29 treated with interferon-beta – IFN-β)]. Results: Levels of 15d-PGJ2 were similar between healthy controls and untreated MS patients with different clinical courses of the disease. Treatment with IFN-β had no effect on levels of 15d-PGJ2. Conclusions: Although these findings suggest that 15d-PGJ2 is not involved in the acute or chronic phases of the disease, further studies measuring 15d-PGJ2 in cerebrospinal fluid samples are needed before excluding a role of 15d-PGJ2 in MS. |
| تدمد: | 1468-1331 1351-5101 |
| DOI: | 10.1111/j.1468-1331.2009.02696.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::73814f40fa4ca1219f9a1bab96dbbf28 https://doi.org/10.1111/j.1468-1331.2009.02696.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........73814f40fa4ca1219f9a1bab96dbbf28 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14681331 13515101 |
|---|---|
| DOI: | 10.1111/j.1468-1331.2009.02696.x |