Antimicrobial and antioxidant properties of novel octa-substituted phthalocyanines bearing (trifluoromethoxy) phenoxy groups on peripheral positions
| العنوان: | Antimicrobial and antioxidant properties of novel octa-substituted phthalocyanines bearing (trifluoromethoxy) phenoxy groups on peripheral positions |
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| المؤلفون: | Hande Pekbelgin Karaoğlu, Mustafa Akin, Neslihan Saki, Makbule Burkut Koçak, Nazli Farajzadeh |
| المصدر: | Journal of Porphyrins and Phthalocyanines. 23:91-102 |
| بيانات النشر: | World Scientific Pub Co Pte Lt, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Antioxidant, Bearing (mechanical), medicine.medical_treatment, General Chemistry, Antimicrobial, Medicinal chemistry, law.invention, Phthalonitrile, chemistry.chemical_compound, chemistry, law, Phthalocyanine, medicine, Derivative (chemistry) |
| الوصف: | This study presents a novel phthalonitrile derivative (2) bearing (trifluoromethoxy)phenoxy groups in 4,5 positions. Cyclotetramerization of (2) in [Formula: see text],[Formula: see text]-dimethylaminoethanol (DMAE) gave a series of peripherally octa-substituted metallophthalocyanines (3-Zn, 3-Co and 3-Cu). The newly synthesized phthalocyanines have been characterized by a combination of various spectroscopic techniques. Effects of solvent nature on aggregation behavior of 3-Zn were studied using different solvents such as acetone, CHCl3 and dichloromethane (DCM). In addition, the aggregation behavior of the phthalocyanine complex 3-Zn was examined in DCM at different concentrations ranging from 4 × 10[Formula: see text]–14 × 10[Formula: see text] M. Antimicrobial activities of synthesized compounds were tested by using the thin layer chromotography (TLC)-direct bioautography and disk diffusion methods. In both assays, the molecules showed activity on the tested Gram (+) bacteria. Antioxidant activities of the molecules, on the other hand, were determined by using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method and a reducing power assay. The highest activity was obtained with 3-ZnPc for both methods. |
| تدمد: | 1099-1409 1088-4246 |
| DOI: | 10.1142/s1088424619500068 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::6f076b4228522782ece56a92b77ada55 https://doi.org/10.1142/s1088424619500068 |
| رقم الانضمام: | edsair.doi...........6f076b4228522782ece56a92b77ada55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991409 10884246 |
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| DOI: | 10.1142/s1088424619500068 |