Activated platelets in subjects at increased risk of IDDM
| العنوان: | Activated platelets in subjects at increased risk of IDDM |
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| المؤلفون: | D. Tschoepe, E. Driesch, B. Schwippert, E. F. Lampeter, Study Group DENIS |
| المصدر: | Diabetologia. 40:573-577 |
| بيانات النشر: | Springer Science and Business Media LLC, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | medicine.medical_specialty, Thrombospondin, P-selectin, business.industry, Endocrinology, Diabetes and Metabolism, medicine.disease, Platelet membrane glycoprotein, Endocrinology, Diabetes mellitus, Internal medicine, Metabolic control analysis, Internal Medicine, medicine, Platelet, Platelet activation, business, Thrombospondins |
| الوصف: | Activated platelets respond to activated leukocytes and endothelial cells via adhesion molecules linking inflammation and thrombosis. Platelets of recent-onset insulin-dependent diabetic (IDDM) patients have been shown to be activated independent of metabolic control. This study evaluates the levels of circulating activated platelets exposing adhesion molecules in healthy subjects at increased risk of IDDM (surface markers were: P-selectin (CD62), thrombospondin, lysosomal GP53 (CD63). From the DENIS and the ENDIT screening programmes 19 identified islet cell antibody positive (titre > or = 20 Juvenile Diabetes Foundation units) first degree relatives of IDDM patients (male/female 9/10; age 22 +/- 15 years; body mass index (BMI): 20.0 +/- 4.3 kg/m2) with clearly normal metabolism (HbA1: 6.1 +/- 0.8%; fasting blood glucose: 4.95 +/- 0.67 mmol/l) were available for this investigation. Platelet CD62 as well as thrombospondin and CD63 expression were determined by flow cytometry. We matched 50 normal volunteers for age (29 +/- 6 years), anthropometric measures (male/female 26/24; BMI: 22.3 +/- 2.8 kg/m2) and metabolic parameters (HbA1: 5.8% +/- 0.3; fasting blood glucose: 4.41 +/- 0.53 mmol/1) served as control subjects. The mean number of CD62+ platelets was increased 3.2-times in prediabetic patients: 1.94 x 2.91 (+/- 1) vs 0.60 x 1.83 (+/- 1%), p < 0.0001. Thrombospondin+ and CD63+ platelet levels were concomitantly increased (1.45 x 2.38( +/- 1)/5.97 x 2.89 (+/- 1)% vs 0.52 x 2.01 (+/-1)/1.64 x 2.26 (+/-1)%, p < 0.0001 for both comparisons). Thus, intravasal platelet activation is already present in potentially prediabetic subjects representing an antecedent, potentially pathogenic feature of IDDM. |
| تدمد: | 1432-0428 0012-186X |
| DOI: | 10.1007/s001250050717 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::6b260a05242e84486ccd1740e68c82bf https://doi.org/10.1007/s001250050717 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........6b260a05242e84486ccd1740e68c82bf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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| DOI: | 10.1007/s001250050717 |