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Effect of Pentoxifylline, ethacrynic acid and O6-benzyl-guanine as resistance modifiers to alkylating agents in haematological malignancies

التفاصيل البيبلوغرافية
العنوان: Effect of Pentoxifylline, ethacrynic acid and O6-benzyl-guanine as resistance modifiers to alkylating agents in haematological malignancies
المؤلفون: M. R. Nowrousian, M. R. Müller, Siegfried Seeber, Chr. Boogen, L. Schlenger
المصدر: Cancer Treatment An Update ISBN: 9782817807676
بيانات النشر: Springer Paris, 1994.
سنة النشر: 1994
مصطلحات موضوعية: Chronic lymphatic leukaemia, chemistry.chemical_compound, Biochemistry, chemistry, Guanine, Nonprotein thiol, Detoxification, medicine, Glutathione, Healthy donor, Cytotoxicity, Pentoxifylline, medicine.drug
الوصف: Cellular resistance to alkylating agents is probably a multifactorial event including several detoxification pathways. In cell lines, the principal cellular nonprotein thiol glutathione (GSH) reacts with several cytotoxic agents by conjugation reaction catalysed by Glutathione-S-transferases (GST). Circumvention of GSH-mediated resistance may thus be achieved by blocking of GSTs. EA has been shown to inhibit GSTs and to enhance chemosensitivity to alkylating agents in cell lines.
ردمك: 978-2-8178-0767-6
DOI: 10.1007/978-2-8178-0765-2_158
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::692d05f50aebd003d061cd439dc5fb20
https://doi.org/10.1007/978-2-8178-0765-2_158
رقم الانضمام: edsair.doi...........692d05f50aebd003d061cd439dc5fb20
قاعدة البيانات: OpenAIRE
الوصف
ردمك:9782817807676
DOI:10.1007/978-2-8178-0765-2_158