Abstract B76: MicroRNAs regulate cell phenotype and N-myc expression in human neuroblastoma cells
| العنوان: | Abstract B76: MicroRNAs regulate cell phenotype and N-myc expression in human neuroblastoma cells |
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| المؤلفون: | Barbara A. Spengler, Kathryn B. Grandinetti, Ruojun Huang, Robert A. Ross, Leleesha Samaraweera |
| المصدر: | Cancer Research. 69:B76-B76 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Neuroblastoma cell, Cancer Research, Cell phenotype, Oncology, microRNA, Cancer research, Biology |
| الوصف: | Identification of miRNAs that regulate neuroblast growth and differentiation could be important in understanding the onset and progression of the childhood cancer neuroblastoma, and in developing new therapeutics to fight this often fatal disease. Neuroblastoma tumors and derived cell lines are heterogeneous, with three basic phenotypes - neuroblastic (N), substrate-adherent (S), and cancer stem cells (I). These types differ significantly in their morphology, biochemistry and tumorigenic potential. Five miRNAs differentially expressed with respect to cell phenotype were identified from a miRNA microarray, validated by RT-PCR, and quantified by real-time RT-PCR taqman assays in 14 different cell lines (6 N-, 5 I- and 3 S-types). Out of these miRNAs, three are highly expressed in non-tumorigenic S-type cell lines compared to I- and N-type cell lines: miR-21 (10- fold, p Citation Information: Cancer Res 2009;69(23 Suppl):B76. |
| تدمد: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.fbcr09-b76 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::604ba95668593c59968288c6f0e0072d https://doi.org/10.1158/0008-5472.fbcr09-b76 |
| رقم الانضمام: | edsair.doi...........604ba95668593c59968288c6f0e0072d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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| DOI: | 10.1158/0008-5472.fbcr09-b76 |