Synthesis of 3-adamantylated hydantoins and their 2-thio(seleno) analogs
| العنوان: | Synthesis of 3-adamantylated hydantoins and their 2-thio(seleno) analogs |
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| المؤلفون: | Vladimir S. D’yachenko, Dmitry Pitushkin, V. V. Burmistrov, Gennady M. Butov, Vladimir V. Vasipov |
| المصدر: | Chemistry of Heterocyclic Compounds. 55:619-622 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | chemistry.chemical_compound, chemistry, 010405 organic chemistry, Hydrochloride, Organic Chemistry, Thio, 010402 general chemistry, Glycine ethyl ester, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences |
| الوصف: | A series of 3-(adamantan-1-ylalkyl)-2-(O,S,Se)hydantoins were synthesized in the reaction of (adamantan-1-ylalkyl)heteroallenes with glycine ethyl ester hydrochloride under mild conditions in 75–85% yields. A method was developed for the synthesis of novel adamantan-1-ylalkyl isoselenocyanates, precursors in the synthesis of adamantylated 2-selenohydantoins. For the first time, 3-(adamantan-1-yl)-2-(O,S)hydantoins were synthesized via the reaction of 2-(O,S)hydantoins with 1,3-dehydroadamantane in 1,4-dioxane heated to reflux for 1 h in 75–80% yields. |
| تدمد: | 1573-8353 0009-3122 |
| DOI: | 10.1007/s10593-019-02507-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::603496f8254b841d49a93b179a2ab020 https://doi.org/10.1007/s10593-019-02507-4 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........603496f8254b841d49a93b179a2ab020 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15738353 00093122 |
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| DOI: | 10.1007/s10593-019-02507-4 |