Tigecycline as salvage treatment of febrile neutropenia in patients with haematological malignancies—a retrospective single-centre analysis of 200 cases
| العنوان: | Tigecycline as salvage treatment of febrile neutropenia in patients with haematological malignancies—a retrospective single-centre analysis of 200 cases |
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| المؤلفون: | Daniel Geßner, Mirjeta Berisha, Torben Esser, Enrico Schalk |
| المصدر: | Annals of Hematology. |
| بيانات النشر: | Springer Science and Business Media LLC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Hematology, General Medicine |
| الوصف: | Tigecycline has been used to treat patients with febrile neutropenia (FN). This study aims to analyse the effectiveness of tigecycline as salvage treatment of FN. Patients records from 09/2004 to 04/2019 were reviewed. Cases were eligible if fever persisted/recurred (p/r-FN) after 3 days of second-line treatment with a carbapenem, and were divided into three groups: switch to tigecycline (TGC group), switch to other antibiotics (OAB group), and no switch (W&W group). The primary endpoint was response rate (defervescence for ≥ 7 days or at least until discharge); the key secondary endpoint was 30-day mortality rate. Two hundred cases from 176 patients (median 59 years; 53.5% men) treated were included, mostly acute myeloid leukaemias (61.0%). 45.5% of cases were in the TGC group (in combination with an anti-pseudomonal antibiotic, mostly ceftazidime [95.6%]); 35.5% were in the OAB and 19.0% in the W&W group. There was no significant difference in response rates (TGC, 73.6%; OAB, 62.0%; W&W, 78.9%; p = 0.12) or 30-day mortality rates (TGC, 7.7%; OAB, 7.0%; W&W, 5.3%; p = 0.94). Tigecycline plus an anti-pseudomonal antibiotic does not improve response or 30-day mortality rate compared to other antibiotics in patients with p/r-FN. Also, in some cases, no switch in antibiotics may be necessary at all. |
| تدمد: | 1432-0584 0939-5555 |
| DOI: | 10.1007/s00277-023-05222-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5f151348fd19fa038ccbb05c4ab33326 https://doi.org/10.1007/s00277-023-05222-5 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........5f151348fd19fa038ccbb05c4ab33326 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320584 09395555 |
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| DOI: | 10.1007/s00277-023-05222-5 |