The role of cardiometabolic risk factors and endothelial dysfunction in serum albumin levels and capillary leak syndrome of patients with COVID-19
| العنوان: | The role of cardiometabolic risk factors and endothelial dysfunction in serum albumin levels and capillary leak syndrome of patients with COVID-19 |
|---|---|
| المؤلفون: | E Oikonomou, S Lampsas, V Lampadiari, E Korakas, E Bletsa, N Souvaliotis, P Theofilis, A Tsatsaragkou, G Poulakou, D Tsoukalas, P Pantelidis, S M Kyvelou, G Siasos, D Tousoulis, M Vavuranakis |
| المصدر: | European Heart Journal. 43 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background Growing evidence focuses on the role of hypoalbuminemia in the COVID-19 course and the role of vascular inflammation in the progression to Capillary Leak Syndrome (CLS). CLS may be mediated by a derangement of endothelial barrier following vascular endothelial dysfunction. We investigated the role of cardiometabolic risk factors in the association of hypoalbuminemia with endothelial dysfunction of hospitalized COVID-19 patients. Methods In this cross-sectional study, patients hospitalized for COVID-19 at the medical ward or Intensive Care Unit (ICU) were enrolled. Medical history and laboratory examinations were collected while the endothelial function was assessed by brachial artery flow-mediated dilation (FMD) between the first 24–72 hours of their admission to the hospital. According to the body mass index, history of hypertension, dyslipidemia, and diabetes mellitus, COVID-19 patients were categorized in those with Cardiometabolic Risk Factors (CRFact) or without CRFact (no-CRFact). From the study population, we excluded subjects with established cardiovascular disease. Results Sixty-six patients with COVID-19 (37% admitted in ICU) were recruited. From the study population, 41 were in the group of CRFact and 25 in the no-CRFact. Patients with CFRact were older (65±9 years vs. 53±14 years, p Conclusion COVID-19 patients with cardiometabolic risk factors present with low serum albumin levels early at the course of the disease, which may be driven by endothelial dysfunction and vascular inflammation. This data gives insights into the potential association of a dysfunctional endothelial layer and the progression to capillary leak syndrome. Funding Acknowledgement Type of funding sources: None. |
| تدمد: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehac544.1955 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5eb867f8d349e036cbbeece7e3b1981f https://doi.org/10.1093/eurheartj/ehac544.1955 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........5eb867f8d349e036cbbeece7e3b1981f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
|---|---|
| DOI: | 10.1093/eurheartj/ehac544.1955 |