The absolute stereochemistry of nebularine-methanol photoadduct. A potential transition-state analog of adenosine deaminase
| العنوان: | The absolute stereochemistry of nebularine-methanol photoadduct. A potential transition-state analog of adenosine deaminase |
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| المؤلفون: | Yoichi Iitaka, Masami Shimazaki, Masaji Ohno, Hikaru Nakamura |
| المصدر: | Chemical and Pharmaceutical Bulletin. 31:3104-3112 |
| بيانات النشر: | Pharmaceutical Society of Japan, 1983. |
| سنة النشر: | 1983 |
| مصطلحات موضوعية: | Purine, Addition reaction, biology, Stereochemistry, General Chemistry, General Medicine, Ribonucleoside, Coformycin, chemistry.chemical_compound, Adenosine deaminase, chemistry, Transition state analog, Drug Discovery, biology.protein, Stereoselectivity, Methanol |
| الوصف: | A stereoselective photoaddition of methanol to nebularine and 2', 3', 5'-tri-O-acetylnebularine was investigated. The absolute stereochemistry of the nebularine-methanol photoadduct (2a), a potential transition-state analog of adenosine deaminase, was determined to be 6 (S) by X-ray analysis. The addition site of methanol on the purine ring was also chemically demonstrated to be at C (6). |
| تدمد: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.31.3104 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5e571471187c9cfe2a00f266528f1717 https://doi.org/10.1248/cpb.31.3104 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........5e571471187c9cfe2a00f266528f1717 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13475223 00092363 |
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| DOI: | 10.1248/cpb.31.3104 |