The skin: a site of extralymphoid IgM production
| العنوان: | The skin: a site of extralymphoid IgM production |
|---|---|
| المؤلفون: | Shannon E McGettigan, R. Paul Wilson, Van Duc Dang, Anil Kumar, Neda Nikbakht, William Stohl, Gudrun F Debes |
| المصدر: | The Journal of Immunology. 202:129.5-129.5 |
| بيانات النشر: | The American Association of Immunologists, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Antibodies are critical to cutaneous host defense and inflammation, but the mechanisms by which skin antibodies are maintained are poorly described. In this study, we found extralymphoid antibody production in unperturbed human and mouse skin. IgM was the predominant isotype produced by plasma cells in healthy murine skin and was also secreted in healthy human skin. In mice, cutaneous IgM plasma cells were independent of T cells and microbiota. Importantly, chronic inflammation caused the massive accumulation of IgM secreting cells that was dependent on APRIL or BAFF in skin but not in other sites. In addition, skin immunization caused cutaneous accumulation of both T cell-dependent and -independent antigen-specific IgM secreting cells. Thus, we reveal the skin as a novel niche for plasma cells with important implications for the regulation of cutaneous antibodies. We propose that skin plasma cells supply natural and adaptive IgM to the cutaneous environment, thereby supporting homeostatic skin barrier functions in addition to providing defense against pathogen intrusion. |
| تدمد: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.202.supp.129.5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5dc65e942cd2d89224b38b44e3a00dcf https://doi.org/10.4049/jimmunol.202.supp.129.5 |
| رقم الانضمام: | edsair.doi...........5dc65e942cd2d89224b38b44e3a00dcf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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| DOI: | 10.4049/jimmunol.202.supp.129.5 |