High Proportions of CD4+CD25hi T Cells Pretransplant Correlate with Worse Overall Survival after Stem Cell Transplant
| العنوان: | High Proportions of CD4+CD25hi T Cells Pretransplant Correlate with Worse Overall Survival after Stem Cell Transplant |
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| المؤلفون: | Rafael F. Duarte, Bronwen E. Shaw, Neema P. Mayor, J. Alejandro Madrigal, PJ Travers, Stephen G.E. Marsh, Adria Prieto-Hinojosa |
| المصدر: | Blood. 108:3126-3126 |
| بيانات النشر: | American Society of Hematology, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | education.field_of_study, Regulatory T cell, medicine.medical_treatment, Immunology, Population, FOXP3, Cell Biology, Hematology, Human leukocyte antigen, Hematopoietic stem cell transplantation, Biology, Biochemistry, Cytokine, medicine.anatomical_structure, medicine, IL-2 receptor, Stem cell, education |
| الوصف: | Regulatory cells may have a modulatory effect on alloreactive phenomena following hematopoietic stem cell transplantation (HSCT), although their role in this setting in patients remains controversial. We have analysed the effect of pre-conditioning peripheral blood levels of T-regs on the outcome of 89 adult patients undergoing HLA-identical (10/10) unrelated donor (UD)-HSCT. Allografts were T-cell depleted with Alemtuzumab, which has been described to spare T-regs from, and we found that higher proportion of CD4+CD25hi T-cells correlated with worse survival (p=0.002). This higher proportion also correlated with higher incidence of relapse (p=0.0274) and with higher incidence of chronic (c) GvHD (p=0.033) but not with the incidence of aGvHD. Regulatory T cells (T-regs) are a naturally occurring regulatory population of CD4+CD25hi T-cells known to express the transcription repressor FoxP3 and to produce anti-inflammatory cytokines such as TGFβ and may therefore affect patient survival. We analyse the profile of the CD4+CD25hiT cells in our cohort. In our healthy donor control group (n=30), CD4+CD25hi-expression associated with both, FoxP3 mRNA-levels (r=0.649; p=0.001) and TGFβ production (r=0.912; p In summary, CD4+CD25hi Regulatory T cells may have an impact suppressing allo-responses against the tumour, decreasing the overall survival by increasing the rates of relapse. Although, in mice CD4+CD25hi population have been clearly identified by the expression of the FOXP3, which encodes a transcription repressor, in humans this remains controversial, where FOXP3 expression is not exclusive of the CD4+CD25hi population. Relying on the expression of CD4+CD25hi and FOXP3 in patients is insufficient to determine regulatory T cell numbers and suggests that other parameters of regulatory function should be taken in to account. |
| تدمد: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v108.11.3126.3126 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5d5978920a78f14b8707417864463f34 https://doi.org/10.1182/blood.v108.11.3126.3126 |
| رقم الانضمام: | edsair.doi...........5d5978920a78f14b8707417864463f34 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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| DOI: | 10.1182/blood.v108.11.3126.3126 |