Bone-Like Elastomer-Toughened Scaffolds with Degradability Kinetics Matching Healing Rates of Injured Bone

التفاصيل البيبلوغرافية
العنوان: Bone-Like Elastomer-Toughened Scaffolds with Degradability Kinetics Matching Healing Rates of Injured Bone
المؤلفون: Xian Zhou, Paul A. Komesaroff, George Anthony Thouas, Julian M.W. Quinn, Qizhi Chen
المصدر: Advanced Engineering Materials. 12:B642-B648
بيانات النشر: Wiley, 2010.
سنة النشر: 2010
مصطلحات موضوعية: Scaffold, Materials science, Kinetics, Biomaterial, Condensed Matter Physics, Bone tissue, Elastomer, Bone tissue engineering, medicine.anatomical_structure, Healing rate, medicine, General Materials Science, Cancellous bone, Biomedical engineering
الوصف: Biomaterial scaffolds provide a potentially powerful means of creating precisely engineered bone tissue substitutes with appropriate architecture and mechanical properties. Despite many efforts, there are few satisfactory products available for clinical use, and significant challenges remain in the design of smart constructs, especially for mechanically functional scaffolds. For successful long-term repair of bone, a scaffold must be strong yet have degradation kinetics matching the healing rate of remodeling bone. Here we report a new family of elastomer-toughened composite scaffolds fabricated from poly(glycerol sebacate) and Bioglass ® . These synthetic scaffolds have very similar mechanical properties to that of cancellous bone of the same porosity, and exhibit a mechanically steady state over an extended period in a physiologic environment. The second feature is of great importance to bone tissue engineering, where a lag phase of degradation following implantation is highly desirable in order to provide support to the damaged or fragmented bone tissue. This work shows that a mechanically smart construct with the three-stage profile (lag, log, and plateau phases) of ideal degradation kinetics in mechanical function is achievable with synthetic biomaterials.
تدمد: 1438-1656
DOI: 10.1002/adem.201080002
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5ac803feb9a77b9a10ea9cc16e2bd4de
https://doi.org/10.1002/adem.201080002
Rights: CLOSED
رقم الانضمام: edsair.doi...........5ac803feb9a77b9a10ea9cc16e2bd4de
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14381656
DOI:10.1002/adem.201080002