Effect of Impaired Lung Function on the Development and Progression of Endobronchial Premalignant Lesions
| العنوان: | Effect of Impaired Lung Function on the Development and Progression of Endobronchial Premalignant Lesions |
|---|---|
| المؤلفون: | Mary E. Reid, Samjot Singh Dhillon, Gregory M. Loewen, Sai Yendamuri, D. Kyle Hogarth, Ravi Menezes, Enrique Machare-Delgado, Martin C. Mahoney, Vijayvel Jayaprakash, Sandra M. Jacob |
| المصدر: | Journal of Cancer Therapy. :364-371 |
| بيانات النشر: | Scientific Research Publishing, Inc., 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Spirometry, medicine.medical_specialty, COPD, medicine.diagnostic_test, business.industry, medicine.disease, Gastroenterology, Squamous metaplasia, Pulmonary function testing, Surgery, Lesion, Dysplasia, Internal medicine, Carcinoma, Medicine, medicine.symptom, business, Lung cancer |
| الوصف: | Background: Chronic obstructive pulmonary disease (COPD) and presence of endobronchial premalignant lesions (EPL) are individual risk factors for lung cancer (LC). However, effect of impaired lung function (ILF) on the natural history of EPL has not been explored. Patients and Methods: This study included 217 high-risk participants from a hospital-based LC surveillance cohort who underwent pulmonary function testing followed by bronchoscopy with endobronchial biopsies. Baseline histopathology diagnoses included 91 cases (41.9%) with squamous metaplasia (SM), 25 (11.5%) with squamous dysplasia (SD), 1 (0.5%) with in-situ carcinoma and 5 (2.3%) with invasive LC. Follow-up biopsies were obtained for 69 patients, and 16 (23.2%) patients demonstrated progression to a higher grade lesion. Regression models were used to evaluate the relationship between ILF and EPL. All the models were adjusted for age, gender and tobacco smoking. Results: Patients with FEV1% of |
| تدمد: | 2151-1942 2151-1934 |
| DOI: | 10.4236/jct.2012.324048 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::56208881812ff0c54b21b5b9d9d14d7a https://doi.org/10.4236/jct.2012.324048 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........56208881812ff0c54b21b5b9d9d14d7a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21511942 21511934 |
|---|---|
| DOI: | 10.4236/jct.2012.324048 |