Anti‐inflammatory effect of alkaloids extracted from Dendrobium aphyllum on macrophage RAW 264.7 cells through NO production and reduced IL‐1, IL‐6, TNF‐α and PGE2 expression
| العنوان: | Anti‐inflammatory effect of alkaloids extracted from Dendrobium aphyllum on macrophage RAW 264.7 cells through NO production and reduced IL‐1, IL‐6, TNF‐α and PGE2 expression |
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| المؤلفون: | Charles Stephen Brennan, Qin Wang, Lukai Ma, Xiaohui Lin, Jihong Wu, Huifan Liu, Jiaxi Liang, Yanfu Li |
| المصدر: | International Journal of Food Science & Technology. 55:1255-1264 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | chemistry.chemical_classification, 0303 health sciences, biology, medicine.drug_class, Dendrobium aphyllum, Alkaloid, Pharmacology, Polysaccharide, biology.organism_classification, Industrial and Manufacturing Engineering, Anti-inflammatory, 03 medical and health sciences, 0302 clinical medicine, chemistry, 030220 oncology & carcinogenesis, biology.protein, medicine, Secretion, Tumor necrosis factor alpha, Interleukin 6, RAW 264.7 Cells, 030304 developmental biology, Food Science |
| الوصف: | Dendrobium aphyllum is an edible plant that is used as a functional food to improve health. We previously examined peptides and polysaccharides extracted from Dendrobium aphyllum; however, we did not investigate D. aphyllum’s alkaloid compounds and their functions. In this study, we detail the composition of alkaloids from Dendrobium aphyllum (DAA), including 2α, 3β‐dihydroxy nortropane, 1‐methyl‐2‐[(4Z,7Z)‐4,7‐tridecadienyl]‐4(1H)‐quinolone and maokonine, which were first identified by UPLC‐MS analysis. Furthermore, the anti‐inflammatory activity of DAA on LPS‐induced RAW 264.7 macrophages was examined. DAA treatment inhibited LPS‐induced NO production and decreased (P |
| تدمد: | 1365-2621 0950-5423 |
| DOI: | 10.1111/ijfs.14404 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::560efe67c3aabee65a567892c5f12837 https://doi.org/10.1111/ijfs.14404 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........560efe67c3aabee65a567892c5f12837 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652621 09505423 |
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| DOI: | 10.1111/ijfs.14404 |