The paper describes the case of two Caucasian brothers (11 and 12 years old resepctively) who for the first time presented with acute haemolysis due to glucose-6-phosphate dehydrogenase deficiency. The two brothers showed different severity of symptoms, even though the elder one had already eaten fava beans before. Of note, both of them were affected by neonatal jaundice and needed phototherapy in their first days of life.