Reductive Alkylation of Hydrazine Derivatives with α-Picoline-Borane and Its Applications to the Syntheses of Useful Compounds Related to Active Pharmaceutical Ingredients
| العنوان: | Reductive Alkylation of Hydrazine Derivatives with α-Picoline-Borane and Its Applications to the Syntheses of Useful Compounds Related to Active Pharmaceutical Ingredients |
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| المؤلفون: | Yasushi Kawase, Teruo Kutsuma, Jun-ya Kato, Takeo Iwakuma, Tadashi Kataoka, Takehiro Yamagishi, Tsutomu Yokomatsu |
| المصدر: | Synthesis. 46:455-464 |
| بيانات النشر: | Georg Thieme Verlag KG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Active ingredient, Isocarboxazid, Organic Chemistry, Alkylation, Borane, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, chemistry, Reagent, medicine, Picoline, Hydrazine derivatives, medicine.drug |
| الوصف: | An efficient method for the direct reductive alkylation of hydrazine derivatives with α-picoline-borane has been developed to synthesize a variety of N-alkylhydrazine derivatives. This method provided N,N-dialkylhydrazine derivatives and N-monoalkylhydrazine derivatives upon fine-tuning of the substrates and the reagent equivalency in a one-pot manner. The method was applied to the synthesis of active pharmaceutical ingredients of therapeutic drugs such as isocarboxazid. |
| تدمد: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0033-1340484 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5358a824cb98685ec72eea61af20477a https://doi.org/10.1055/s-0033-1340484 |
| رقم الانضمام: | edsair.doi...........5358a824cb98685ec72eea61af20477a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1437210X 00397881 |
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| DOI: | 10.1055/s-0033-1340484 |