G Protein Subunit Gα 13 Binds to Integrin α IIb β 3 and Mediates Integrin 'Outside-In' Signaling
| العنوان: | G Protein Subunit Gα 13 Binds to Integrin α IIb β 3 and Mediates Integrin 'Outside-In' Signaling |
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| المؤلفون: | Stephen C.-T. Lam, Tatyana A. Voyno-Yasenetskaya, Xiaoping Du, Tohru Kozasa, Panagiotis Flevaris, Haixia Gong, Bo Shen, Christina Chow |
| المصدر: | Science. 327:340-343 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Multidisciplinary, RHOA, biology, Integrin alpha M, G protein, Heterotrimeric G protein, Integrin, biology.protein, Integrin, beta 6, Molecular biology, CD49c, Cell biology, Collagen receptor |
| الوصف: | Integrin G Protein Adhesion molecules, known as integrins, are found on the surface of cells. When integrins adhere to components of the extracellular matrix, they act as receptors and initiate signaling events within the cell. Gong et al. (p. 340 ) show that they do so in part by partnering with a signal-transducing protein called Gα 13 . Such α subunits of heterotrimeric guanine nucleotide-binding proteins are well known for transducing signals from the large class of G protein–coupled receptors, but were not known to work with integrins. Gα 13 appears to interact directly with the integrin α IIb β 3 and to transmit signals that regulate cell spreading. |
| تدمد: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1174779 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::532cb32e0b201973a8724d42355733bb https://doi.org/10.1126/science.1174779 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........532cb32e0b201973a8724d42355733bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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| DOI: | 10.1126/science.1174779 |