ent-Kaurane-Based Diterpenoids, Dimers, and Meroditerpenoids from Isodon xerophilus
| العنوان: | ent-Kaurane-Based Diterpenoids, Dimers, and Meroditerpenoids from Isodon xerophilus |
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| المؤلفون: | Xiao-Nian Li, Kun Hu, Han-Dong Sun, Bing-Chao Yan, Pema-Tenzin Puno, Jia-Meng Dai, Xing-Ren Li |
| المصدر: | Journal of Natural Products. 83:3717-3725 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pharmacology, Quantum chemical, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), 010405 organic chemistry, Chemistry, Stereochemistry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Chemical shift, Organic Chemistry, Pharmaceutical Science, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, Drug Discovery, Molecular Medicine, No production, Isodon xerophilus, Ent kaurane |
| الوصف: | Eight new diterpenoids (1-8) with varied structures were isolated from the aerial parts of Isodon xerophilus. Among them, xerophilsin A (1) was found to be an unusual meroditerpenoid representing a hybrid of an ent-kauranoid and a long-chain aliphatic ester, xerophilsins B-D (2-4) are dimeric ent-kauranoids, while xerophilsins E-H (5-8) are new ent-kauranoids. The structures of 1-8 were elucidated mainly through the analyses of their spectroscopic data. The absolute configurations of 2, 6, and 8 were confirmed by single-crystal X-ray diffraction, and the configuration of C-16 in 7 was established through quantum chemical calculation of NMR chemical shifts, as well as modeling of key interproton distances. Bioactivity evaluation of all isolated compounds revealed that 2, 3, and 5 inhibited NO production in LPS-stimulated RAW264.7 cells. |
| تدمد: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.0c00983 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5213f4b6e2eaf3bbf6bb199219b9780a https://doi.org/10.1021/acs.jnatprod.0c00983 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........5213f4b6e2eaf3bbf6bb199219b9780a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206025 01633864 |
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| DOI: | 10.1021/acs.jnatprod.0c00983 |