Detecting serum galactomannan to diagnose acute invasive Aspergillus sinusitis: a meta-analysis
| العنوان: | Detecting serum galactomannan to diagnose acute invasive Aspergillus sinusitis: a meta-analysis |
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| المؤلفون: | Wasan F. Almarzouq, Suk Won Chang, Chang Hoon Kim, Jong Gyun Ha, Hyung Ju Cho, Joo Heon Yoon, Na Won Kim, Jae Sung Nam |
| المصدر: | European Archives of Oto-Rhino-Laryngology. 279:793-800 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Receiver operating characteristic, business.industry, General Medicine, Cochrane Library, medicine.disease, Gastroenterology, Likelihood ratios in diagnostic testing, Confidence interval, 03 medical and health sciences, Galactomannan, chemistry.chemical_compound, 0302 clinical medicine, Otorhinolaryngology, chemistry, 030220 oncology & carcinogenesis, Internal medicine, Meta-analysis, medicine, Diagnostic odds ratio, 030223 otorhinolaryngology, business, Sinusitis |
| الوصف: | The serum galactomannan test has been used for diagnosing acute invasive fungal sinusitis (AIFS), especially invasive Aspergillus. We aimed to assess the accuracy of the test to diagnose acute invasive Aspergillus sinusitis (AIAS). We searched all relevant articles published in PubMed, Embase, the Cochrane Library, and Web of Science databases up until September 14, 2020. The available data for serum galactomannan test to diagnose AIAS from selected studies were assessed. The diagnostic odds ratio (DOR), summary receiver operating characteristics (SROC), sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were estimated. Additionally, we analysed four studies with a cut-off value of 0.5. Five eligible articles were selected in this study. The total number of enrolled patients was 118, and 62 patients had confirmed AIAS. Among these 62 patients, the summary estimates of the serum galactomannan assay were as follows: DOR, 3.37 (95% confidence interval [CI]: 1.47–6.66); sensitivity, 0.63 (95% CI 0.50–0.74); specificity, 0.65 (95% CI 0.51–0.76); PLR, 1.83 (95% CI 1.21–2.74); NLR, 0.58 (95% CI 0.39–0.83). The SROC was 0.68. In this current meta-analysis, the serum galactomannan test was classified as less accurate for purposes of diagnosing confirmed AIAS. These results suggest that the initial diagnosis of AIAS should not solely be dependent upon serum galactomannan test results. More studies of the test are needed in patients with AIAS to more accurately assess its diagnostic value. |
| تدمد: | 1434-4726 0937-4477 |
| DOI: | 10.1007/s00405-021-06857-8 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4d2e65a85b1749e7b1b32c8eb438410d https://doi.org/10.1007/s00405-021-06857-8 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........4d2e65a85b1749e7b1b32c8eb438410d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14344726 09374477 |
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| DOI: | 10.1007/s00405-021-06857-8 |