Preparation and characterization of cellulose/flaxseed gum composite hydrogel and its hemostatic and wound healing functions evaluation
| العنوان: | Preparation and characterization of cellulose/flaxseed gum composite hydrogel and its hemostatic and wound healing functions evaluation |
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| المؤلفون: | Huang Jinyu, Xushan Yang, Jinyuan Chen, Xudong Zhang, Sijie Yuan, Yudi Deng, Wenzhen Liao |
| المصدر: | Cellulose. 27:3971-3988 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Thermogravimetric analysis, Polymers and Plastics, Biocompatibility, Chemistry, Composite number, technology, industry, and agriculture, Biomaterial, macromolecular substances, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, complex mixtures, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Chemical engineering, medicine, Fourier transform infrared spectroscopy, Swelling, medicine.symptom, Cellulose, 0210 nano-technology, Hemostatic function |
| الوصف: | The composite hydrogel was prepared with cellulose and flaxseed gum and characterized by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Brunauer–Emmitt–Teller (BET) and thermogravimetric analysis (TGA). The swelling property, drug adsorption, biocompatibility and hemostatic function of composite hydrogel were investigated. The composite hydrogel had the pore structure and exhibited high stability with a thermal decomposition temperature of 332.66 °C. And the composite hydrogel showed excellent swelling capability with a moisture expansivity of over 200%, and with a drug adsorption capacity of 7.27 ± 0.15 mg/g. Mechanical properties tests showed that as the proportion of flaxseed gum increased, the ability to withstand pressure of hydrogel was improved. In addition, MTT assay, flow cytometry analysis, and in vivo toxicological evaluation suggested that composite hydrogel had good biocompatibility. Moreover, hemostatic potential assay and wound healing were made in order to evaluate the effect of hemostasis and wound healing of composite hydrogel and our results indicated that the composite hydrogel with cellulose and flaxseed gum could be effective to promote hemostatic and wound healing function. All in all, the great properties exhibited by the composite hydrogel could make it a potential candidate as biomaterial in bleeding and wound treatment. |
| تدمد: | 1572-882X 0969-0239 |
| DOI: | 10.1007/s10570-020-03055-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4d052e3ccb7c3b9cfd26b96919c0d97c https://doi.org/10.1007/s10570-020-03055-3 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........4d052e3ccb7c3b9cfd26b96919c0d97c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1572882X 09690239 |
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| DOI: | 10.1007/s10570-020-03055-3 |