DNA Transfection Efficiency of Antimicrobial Peptide as Revealed by Molecular Dynamics Simulation
| العنوان: | DNA Transfection Efficiency of Antimicrobial Peptide as Revealed by Molecular Dynamics Simulation |
|---|---|
| المؤلفون: | Namsrai Javkhlantugs, Janlav Munkhtsetseg, Chimed Ganzorig, Kazuyoshi Ueda |
| المصدر: | MRS Proceedings. 1569:109-114 |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Materials science, Cell, Cationic polymerization, Peptide, Transfection, Molecular biology, Molecular dynamics, chemistry.chemical_compound, medicine.anatomical_structure, Membrane, chemistry, Amphiphile, medicine, Biophysics, DNA |
| الوصف: | The peptide-DNA complex was investigated by using molecular dynamics simulation to analyze the transfection efficiency of cationic amphipathic peptide. Previously, the cationic peptide, LFampinB, with positively charged amino acid residues of Lysines was used to investigate the orientation and interaction energies for entering the cell though disruption of the endosomal membrane. The same interactions were obtained for N-terminus of the LFampinB peptide with membrane and with plasmid DNA. The N-terminus of LFampinB can bind at minor groove of DNA to make complexation of the peptide with DNA. |
| تدمد: | 1946-4274 0272-9172 |
| DOI: | 10.1557/opl.2013.800 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4b696cf753ea147f819abc81c1c39e69 https://doi.org/10.1557/opl.2013.800 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........4b696cf753ea147f819abc81c1c39e69 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19464274 02729172 |
|---|---|
| DOI: | 10.1557/opl.2013.800 |