Synthesis of a 3-keto bicyclic pyrazolidinone using a Curtius rearrangement

التفاصيل البيبلوغرافية
العنوان: Synthesis of a 3-keto bicyclic pyrazolidinone using a Curtius rearrangement
المؤلفون: Richard Elmer Holmes, David Andrew Neel, Jonathan W. Paschal
المصدر: Tetrahedron Letters. 37:4891-4894
بيانات النشر: Elsevier BV, 1996.
سنة النشر: 1996
مصطلحات موضوعية: Cephem, Bicyclic molecule, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Ring (chemistry), Protecting group, Biochemistry, Curtius rearrangement
الوصف: The synthesis of bicyclic pyrazolidinone 2 is described. Traditional methods for penem and cephem ring cyclization were found to be unsuccessful and new methodology using a Curtius rearrangement was utilized. The 3-enamine 11 was hydrolysed to the desired β-keto ester 2b without substantial loss of the t-BOC protecting group.
تدمد: 0040-4039
DOI: 10.1016/0040-4039(96)01003-9
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4ade7e2d2e705f659b8be2fbe7150c08
https://doi.org/10.1016/0040-4039(96)01003-9
Rights: CLOSED
رقم الانضمام: edsair.doi...........4ade7e2d2e705f659b8be2fbe7150c08
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00404039
DOI:10.1016/0040-4039(96)01003-9