Optimization of fundamental parameters in routine production of 90Y-hydroxyapatite for radiosynovectomy
| العنوان: | Optimization of fundamental parameters in routine production of 90Y-hydroxyapatite for radiosynovectomy |
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| المؤلفون: | M R Davarpanah, Mohammad Mazidi, Mohsen Harati, Hossein A. Khoshhosn, Masoumeh Zoghi, M. Ghannadi Maragheh, S. Attar Nosrati |
| المصدر: | Journal of Radioanalytical and Nuclear Chemistry. 302:69-77 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Biodistribution, Chemistry, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Human albumin, Pollution, Analytical Chemistry, Suspension (chemistry), Colloid, Adsorption, Nuclear Energy and Engineering, Elemental analysis, Yield (chemistry), Radiology, Nuclear Medicine and imaging, Inductively coupled plasma, Spectroscopy, Nuclear chemistry |
| الوصف: | Hydroxyapatite was applied as a carrier adsorbing 90Y3+ ions for 90Y-HA colloid production. The radiopharmaceutical colloid was prepared by adding an acidic solution of 90YCl3 to HA suspension in saline solution. Effective parameters on labeling of 90Y-HA were evaluated. Adsorption and cation-exchange properties were studied using inductively coupled plasma elemental analysis and N2 adsorption–desorption isotherm method. Radionuclidic purity was over 99.9 %. Labeling yield and radiochemical purity were >99 %. Radiochemical purity was evaluated also in human albumin for 7 days at 37 °C. Biodistribution studies have shown complete retention of injected radioactivity at the administration site up to 72 h. |
| تدمد: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-014-3326-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4adbae6d33ddbbeeef4650e4462b7f3e https://doi.org/10.1007/s10967-014-3326-4 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........4adbae6d33ddbbeeef4650e4462b7f3e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15882780 02365731 |
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| DOI: | 10.1007/s10967-014-3326-4 |