Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis
| العنوان: | Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis |
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| المؤلفون: | Edward J. Fudman, James W. Thomas, Jane Box, Robert F. Willkens, Robert G. Berger, Murray B. Urowitz, Donald M. Stablein, Yvonne R. S. Sherrer, Muhammad B. Yunus, Alben G. Goldstein, Frank R. Schmid, N. Paul Hudson, Robert J. R. McKendry, Cara R. Marks, Raye H. Brooks, Theodore W. Rooney, Bernard R. Rubin, Robert L. Wortmann, Justus J. Fiechtner, Allen M. Segal |
| المصدر: | Arthritis & Rheumatism. 35:849-856 |
| بيانات النشر: | Wiley, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | musculoskeletal diseases, medicine.medical_specialty, Dose, business.industry, Immunology, Azathioprine, Pharmacology, medicine.disease, Gastroenterology, Discontinuation, law.invention, Rheumatology, Randomized controlled trial, law, Internal medicine, Rheumatoid arthritis, Toxicity, medicine, Immunology and Allergy, heterocyclic compounds, Pharmacology (medical), Methotrexate, Adverse Experience, business, medicine.drug |
| الوصف: | Objective. To assess the relative efficacy of methotrexate (MTX), azathioprine (AZA), and their combination in the treatment of rheumatoid arthritis (RA) in a double-blind, prospective, multicenter, controlled trial. Methods. Two hundred nine patients with active RA were treated with escalating doses of MTX (5–15 mg/week), AZA (50–150 mg/day), or combination (5 mg MTX/week plus 50 mg AZA/day–7.5 mg MTX/week plus 100 mg AZA/day), with opportunity to increase the dosage at 6-w eek intervals. The patients were evaluated for significant clinical and laboratory improvement and assessed for radiologic progression at 48 weeks. Results. One hundred ten patients remained on the initial, randomly assigned therapeutic regimen. The percentage of patients who were responders, defined as those who had 30% or greater improvement in at least 3 of 4 variables, was 38% for the combination treatment, 26% for AZA, and 45% for MTX (P = 0.06). A trend toward decreased radiologic progression was seen in the MTX-treated patients. Termination of treatment due to adverse experience occurred more frequently with combination and AZA treatments than with MTX treatment. Lack of effectiveness, adverse gastrointestinal effects, and liver enzyme elevation were the most frequent causes of treatment discontinuation. Conclusion. This study establishes that the combination of MTX and AZA in the dosages utilized is not associated with more toxicity than treatment with single agents; however, enhanced efficacy is also not seen. There is a trend toward decreased radiologic progression in patients treated with MTX. |
| تدمد: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.1780350802 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::49ce6626cb4c394d6cb3af62711cd527 https://doi.org/10.1002/art.1780350802 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........49ce6626cb4c394d6cb3af62711cd527 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15290131 00043591 |
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| DOI: | 10.1002/art.1780350802 |