Nodular cast iron (NCI) experiences failure under static loading in manner of nucleation, growth, and coalescence of voids. Under cyclic loading, materials with elastic-plastic behaviour show an increase in porosity with each cycle which is called void ratchetting. A number of finite element studies in literature proved this mechanism by means of a few cyles with unit cell models. In the present study, low cycle fatigue (LCF) in nodular cast iron is investigated using the cell models for void ratchetting till final failure. The cyclic necking due to plastic strain accumulation is observed as mechanism in the final stage. The proposed methodology uses only input parameters defining the elastic-plastic material behavior and geometrical features of the microstructure. The strain-life curves extracted from the simulations are compared with experimental data collected from the literature. From the comparison, it is confirmed that void ratchetting is the relevant mechanism of LCF in NCI. The effects of material strength, temperature and load sequencing on the fatigue behaviour are studied.