Serologic characterization of a monkey antiserum to human leukemic myeloblasts
| العنوان: | Serologic characterization of a monkey antiserum to human leukemic myeloblasts |
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| المؤلفون: | D. A. K. Roncari, Robert N. Taub, T. Mohanakumar, Michael A. Baker |
| المصدر: | Blood. 56:934-936 |
| بيانات النشر: | American Society of Hematology, 1980. |
| سنة النشر: | 1980 |
| مصطلحات موضوعية: | Antiserum, Chemistry, Lymphoblast, Immunology, Cell, Cell Biology, Hematology, Biochemistry, Peripheral blood mononuclear cell, Virology, Serology, medicine.anatomical_structure, Immunization, medicine, Bone marrow, Cytotoxicity |
| الوصف: | We have raised a monkey antiserum that is selectively reactive with human leukemic myeloblasts by immunization with a glycoprotein antigen (AMLSGA) released from myeloblasts in short-term culture. Antimyeloblast activity can be demonstrated using complement-dependent cytotoxicity or indirect immunofluorescence. Selective antimyeloblast activity is retained following absorption with leukemic lymphoblasts or lymphocytes, nonleukemic lymphocytes, neutrophils, or mononuclear cells from nonleukemic bone marrow. Anti-AMLSGA antisera are not reactive with B-cell-enriched cell populations, and antaimyeloblast activity is not reduced by absorption with Ia-positive cells. Anti-AMLSGA is a useful reagent for identification of human leukemic myeloblasts. |
| تدمد: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v56.5.934.934 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::4085e74f12bd486f5b6d848d2e4c8e44 https://doi.org/10.1182/blood.v56.5.934.934 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........4085e74f12bd486f5b6d848d2e4c8e44 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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| DOI: | 10.1182/blood.v56.5.934.934 |