Nitrogen doped carbon quantum dots demonstrate no toxicity underin vitroconditions in a cervical cell line andin vivoin Swiss albino mice
| العنوان: | Nitrogen doped carbon quantum dots demonstrate no toxicity underin vitroconditions in a cervical cell line andin vivoin Swiss albino mice |
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| المؤلفون: | Santosh Kumar Singh, Umakant Yadav, Ajay Singh, Anchal Srivastava, Sunayana Kashyap, Rajesh Kumar Singh, Vimal Singh, Preeti S. Saxena |
| المصدر: | Toxicology Research. 8:395-406 |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0303 health sciences, Antioxidant, biology, Chemistry, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Context (language use), 010501 environmental sciences, Toxicology, biology.organism_classification, 01 natural sciences, In vitro, HeLa, 03 medical and health sciences, Apoptosis, In vivo, Toxicity, medicine, Biophysics, DNA fragmentation, 030304 developmental biology, 0105 earth and related environmental sciences |
| الوصف: | Carbon quantum dots (CQDs) and their derivatives have potential applications in the field of biomedical imaging. Toxicity is one of the critical parameters that can hamper their success in biological applications. In this context, our goal was to systematically investigate both in vivo and in vitro toxicity of nitrogen doped carbon quantum dots (NCQDs). In vivo toxic effects were evaluated for 30 days in Swiss albino mice at two different concentrations (5.0 mg per kg body weight (BW) and 10.0 mg per kg BW) of NCQDs. Results of haematological, serum biochemical, antioxidant and histopathological parameters showed no noteworthy defects at both of these concentrations. An in vitro assessment was performed against the human cervical cancer cell line (HeLa cells) at the concentration of 0-400 μg ml-1. The LDH profile, DNA fragmentation, apoptosis, and growth cycle of cells showed no apparent toxicity of NCQDs. The overall study offers highly biocompatible N-doped carbon quantum dots, which may be considered as an attractive material for future biomedical applications. |
| تدمد: | 2045-4538 2045-452X |
| DOI: | 10.1039/c8tx00260f |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3fe4f16cdac1c6b12ebda899c27ab138 https://doi.org/10.1039/c8tx00260f |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........3fe4f16cdac1c6b12ebda899c27ab138 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20454538 2045452X |
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| DOI: | 10.1039/c8tx00260f |