Modified Physicochemical Properties of Acidic Model Drugs Immobilized on Fe3O4Magnetic Iron Oxide Nanoparticles
| العنوان: | Modified Physicochemical Properties of Acidic Model Drugs Immobilized on Fe3O4Magnetic Iron Oxide Nanoparticles |
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| المؤلفون: | Alicja Defort, Julia Nowak-Jary, Jacek Juliusz Kozioƚ |
| المصدر: | Pharmaceutical Chemistry Journal. 53:1025-1035 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pharmacology, 010405 organic chemistry, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Dynamic light scattering, Permeability (electromagnetism), Drug Discovery, Drug delivery, Lipophilicity, Solubility, Drug carrier, Dissolution, Iron oxide nanoparticles, Nuclear chemistry |
| الوصف: | Nanoparticles are now extensively evaluated as drug carriers. The main objective of the present work was to evaluate the difference in physicochemical properties (solubility, permeability, lipophilicity) between acidic drugs immobilized on magnetic iron oxide nanoparticles and the same drugs in their unbound form. Synthesis of Fe3O4 magnetic iron oxide nanoparticles coated with (3-aminopropyl)triethoxysilane (APTES) was carried out with the chosen drugs attached. The obtained nanostructures were characterized using IR spectroscopy, atomic force microscopy (AFM), vibrating sample magnetometry (VSM) and dynamic light scattering (DLS) techniques, and physicochemical properties of the immobilized drugs were studied. The drug solubility was measured using the saturation shake-flask method. The permeability was measured using dialysis membranes, MWCO 50 kD with pores |
| تدمد: | 1573-9031 0091-150X |
| DOI: | 10.1007/s11094-020-02118-w |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3f816a1423003fb79a841f1211386595 https://doi.org/10.1007/s11094-020-02118-w |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........3f816a1423003fb79a841f1211386595 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15739031 0091150X |
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| DOI: | 10.1007/s11094-020-02118-w |