The optimal method of assessing and reducing preprocedural patient anxiety remains uncertain in radiologic procedures. Previous research suggests that the role of radiology nurses is critical to optimally address preprocedural anxiety, but the preferences of radiology nurses remain understudied. A questionnaire was adapted from a previous cross-sectional study of interventional radiology to determine the views of current preferences of nurses with regards to addressing preprocedural anxiety. The questionnaire was disseminated to an e-mail list maintained by the Association for Radiologic and Imaging Nursing (ARIN) from July to September 2019. The survey included questions about the assessment, importance, and reduction of preprocedural patient anxiety. A post hoc scale was used to quantify degree of responsibility allocated to radiology nurses, radiologists, patients, family members, and other health care providers. A total of 370 responses were obtained (18.1% response rate). Most respondents found preprocedural anxiety to be very important in practice (n = 237, 4.4%) and to patients (n = 300, 81.7%). Nurses indicated that anxiety interfered with delivery of care (n = 220, 60.3%) and most respondents formally assessed it in their patients (n = 227, 61.7%). A variety of methods to reduce preprocedural patient were endorsed: patient education (n = 341, 94.2%); empathetic communication (n = 333, 92.0%); anxiety medication (n = 239, 66.0%); permitting family presence (n = 228, 63.0%); familiarization with the facility (n = 97, 26.8%); traditional, complementary, and alternative medication (n = 69, 19.1%). Nurses held themselves most responsible to manage patient anxiety followed by radiologists, patients, family members, primary care providers, and mental health care providers. This study suggests that radiology nurses acknowledge the importance of assessing and reducing preprocedural patient anxiety. Furthermore, radiology nurses use a variety of methods to manage patient anxiety and hold themselves most responsible to reduce anxiety but also allocate responsibility to others such as radiologists and patients.