Detection of long-lived contaminants in cyclotron-produced radiopharmaceuticals by large area plastic scintillators
| العنوان: | Detection of long-lived contaminants in cyclotron-produced radiopharmaceuticals by large area plastic scintillators |
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| المؤلفون: | Kenneth A. Van Riper, Keith F. Eckerman, Robert L. Metzger, Richard W. Leggett |
| المصدر: | Journal of Radioanalytical and Nuclear Chemistry. 318:11-15 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Isotope, Health, Toxicology and Mutagenesis, Radiochemistry, Cyclotron, Public Health, Environmental and Occupational Health, Contamination, Scintillator, 010403 inorganic & nuclear chemistry, 01 natural sciences, Pollution, 030218 nuclear medicine & medical imaging, 0104 chemical sciences, Analytical Chemistry, law.invention, 03 medical and health sciences, 0302 clinical medicine, Nuclear Energy and Engineering, law, Environmental science, Radiology, Nuclear Medicine and imaging, Spallation, Patient dose, In patient, Spectroscopy |
| الوصف: | In the USA during 2015 over 1,718,500 clinical PET scans were performed in 2380 centers. Patients undergoing these studies will alarm homeland security monitors at borders, ports, and some airports for up to 2 days due to the positron-annihilation photons (0.511 MeV) from the imaging isotope 18F (110 min half-life). In some radiopharmaceuticals, long-lived contaminants generated from the activation and spallation of elements in the HAVAR window of the cyclotron target may also be present in the patient dose. In this work, we have modeled a typical homeland security portal monitor in MCNP, and determined its sensitivity to each of the possible contaminating isotopes found in PET radiopharmaceuticals when distributed in patient phantoms. These data were combined with the time-dependent uptake/retention functions for the contaminating isotopes, to identify the isotopes that can cause alarms for substantial periods of time after the short-lived imaging agent has decayed away. |
| تدمد: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-018-5971-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3b9995b7a293c30199d93652722f894c https://doi.org/10.1007/s10967-018-5971-5 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........3b9995b7a293c30199d93652722f894c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15882780 02365731 |
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| DOI: | 10.1007/s10967-018-5971-5 |