Acute Kidney Injury and Hemolytic Uremic Syndrome in Severe Pneumococcal Pneumonia—A Retrospective Analysis in Pediatric Intensive Care Unit
| العنوان: | Acute Kidney Injury and Hemolytic Uremic Syndrome in Severe Pneumococcal Pneumonia—A Retrospective Analysis in Pediatric Intensive Care Unit |
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| المؤلفون: | Chon In Kuok, Mei Lam Natalie Hsu, Stephanie Hui Fung Lai, Kin Nam Karen Wong, Winnie Kwai Yu Chan |
| المصدر: | Journal of Pediatric Intensive Care. |
| بيانات النشر: | Georg Thieme Verlag KG, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pediatrics, Perinatology and Child Health, Critical Care and Intensive Care Medicine |
| الوصف: | Objectives: This study aimed to evaluate the prevalence of acute kidney injury (AKI) and hemolytic uremic syndrome (HUS) in severe pediatric pneumonia due to Streptococcus pneumoniae and to identify factors associated with AKI and HUS in these patients. Methods: We retrospectively analyzed pediatric patients who were admitted to our pediatric intensive care unit due to severe pneumococcal pneumonia between 2013 and 2019. Results: Forty-two patients with a median age of 4.3 years were included. Among these patients, 14 (33.3%) developed AKI, including seven (16.7%) stage 1, two (4.8%) stage 2, and five (11.9%) stage 3 AKI. Features of HUS were present in all of the patients with stage 3 AKI, and four required renal replacement therapy (RRT), with a median duration of 10.5 days (range 3 to 16 days). All patients with HUS required mechanical ventilation and inotropic supports. Patients with lower leukocyte and platelet counts, serum sodium and bicarbonate levels, positive urine dipstick (heme or protein ≥ 2 + ), and presence of bacteremia were associated with stage 2 and 3 AKI. Conclusions: Pediatricians should be aware of the relatively high prevalence of kidney involvement in severe pneumococcal pneumonia, with one-third having AKI and 11.9% developing HUS. Majority (80%) of HUS patients required RRT. Positive urine dipstick, serum sodium, and bicarbonate at presentation, which can be measured in point-of-care tests, may potentially be useful as quick tests to stratify the risks of moderate-to-severe AKI. |
| تدمد: | 2146-4626 2146-4618 |
| DOI: | 10.1055/s-0042-1759528 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3b2c7d40b774d849b47da8bc5b2d0168 https://doi.org/10.1055/s-0042-1759528 |
| رقم الانضمام: | edsair.doi...........3b2c7d40b774d849b47da8bc5b2d0168 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21464626 21464618 |
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| DOI: | 10.1055/s-0042-1759528 |