Evaluation of upper reference limit of TSH in adults: Review of biological upper reference limit for TSH on a 'chemiluminescence based' analysis technique
التفاصيل البيبلوغرافية
العنوان:
Evaluation of upper reference limit of TSH in adults: Review of biological upper reference limit for TSH on a 'chemiluminescence based' analysis technique
Background: There was an identified need to review the use of the manufacturer provided upper reference limit (URL) of the thyroid stimulating hormone (TSH) assay for the Indian population. URL's provided by manufacturers are usually based on western populations. This study triggered from our clinical feedback, identified that there is indeed difference for the URL for the Indian population compared to what the manufacturer has provided for the TSH assay. Materials and Method: Prospective study with volunteers from St. John's Medial College Hospital general health check who were pre-screened and selected based on inclusion/exclusion criteria decided for the purpose. We utilised the Access ® range of Chemiluminescence based Immuno assay system from Beckman Coulter Inc., Brea. CA, USA for this study. As indicated in the background, we investigated URL of the TSH assay. Results and Conclusion: Results strongly favored the reduction of the URL to be more suitable for the population covered in this study.