The moisture content of digitalis and other crude drugs was determined by a titrimetric procedure employing Karl Fischer reagent. Residual titration was found to be necessary, the excess of the reagent being titrated with a methanol solution of water. A polarized platinum electrode system served to indicate the end point of the titration. The results obtained compared favorably with the standard ovendrying and toluene-distillation methods. Considerable time is saved by this method of determining moisture in vegetable drugs.