Targeted Therapy Approaches for MET Abnormalities in Non-Small Cell Lung Cancer
| العنوان: | Targeted Therapy Approaches for MET Abnormalities in Non-Small Cell Lung Cancer |
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| المؤلفون: | Paige M. Brodrick, Edward B. Garon |
| المصدر: | Drugs. 81:547-554 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cabozantinib, Crizotinib, biology, business.industry, medicine.medical_treatment, medicine.disease, Receptor tyrosine kinase, Targeted therapy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, 030220 oncology & carcinogenesis, Ficlatuzumab, Cancer research, biology.protein, Medicine, Mesenchymal–epithelial transition, Pharmacology (medical), business, Lung cancer, Tyrosine kinase, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | The tyrosine kinase receptor mesenchymal epithelial transition (MET) is a proto-oncogene that, through the activation of the MET-hepatocyte growth factor (HGF) pathway, encodes a variety of biological processes, including cell development, proliferation, invasion, and migration. Abnormal activation of the MET pathway, occurring through MET protein overexpression, and gene amplification or mutation, can contribute to oncogenesis and has been implicated in non-small cell lung cancer (NSCLC). Though it is associated with poor clinical outcome in NSCLCs, MET overexpression and its role as a therapeutic target remains somewhat elusive due to discrepancies in its occurrence. Unlike MET overexpression, MET amplification has demonstrated a stronger potential as a biomarker for therapeutic treatment, with clinical data indicating a compelling connection between a high MET gene copy number and a high response rate to targeted therapies. However, MET exon 14 skipping mutations, occurring in 3%-4 % of lung adenocarcinomas, are of particular interest, as tumors harboring these mutations have shown a significant response to MET inhibitors. Following the discovery of MET as a potential therapeutic target, extensive clinical studies have proposed three approaches to targeting MET: (1) MET tyrosine kinase inhibitors (TKIs), including crizotinib, capmatinib, tepotinib, savolinitib, and cabozantinib; (2) MET or HGF monoclonal antibodies, including emibetuzumab and ficlatuzumab; and (3) MET or HGF antibody drug conjugates, including telisotuzumab. Herein, we discuss the relevant clinical trials, particularly focusing on the efficacy as well as the safety and tolerability of the treatment options, in the promising field of targeting MET in NSCLC. |
| تدمد: | 1179-1950 0012-6667 |
| DOI: | 10.1007/s40265-021-01477-2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::322b9846006777f037261e4a1111681c https://doi.org/10.1007/s40265-021-01477-2 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........322b9846006777f037261e4a1111681c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11791950 00126667 |
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| DOI: | 10.1007/s40265-021-01477-2 |