Synthesis of a Maskedp -Quinone Methide ? -Lactam as an active metabolite of nocardicins
| العنوان: | Synthesis of a Maskedp -Quinone Methide ? -Lactam as an active metabolite of nocardicins |
|---|---|
| المؤلفون: | Jih Ru Hwu, Shwu-Chen Tsay, Gholam Hossein Hakimelahi |
| المصدر: | Helvetica Chimica Acta. 78:411-420 |
| بيانات النشر: | Wiley, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Stereochemistry, Organic Chemistry, Biological activity, Antimicrobial, Biochemistry, Quinone methide, Catalysis, In vitro, Nocardicin A, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Lactam, Pyridinium, Physical and Theoretical Chemistry, Active metabolite |
| الوصف: | Nocardicin A analogues 30, 34, and 38 as well as the highly strained quinone methide 43 were synthesized. β -Lactam 34 was found biologically active against several Gram-negative microorganisms in vitro; pyridinium N-oxide derivative 38 possessed activity against Gram-positive S. aureus bacterium. Masked p-quinone methide β -lactam 43 exhibited significant antimicrobial activity in vitro. A mechanism involving an oxidation in vivo is proposed for the unprecedented biological properties of nocardicins. |
| تدمد: | 1522-2675 0018-019X |
| DOI: | 10.1002/hlca.19950780212 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::3178d5b2f521786187774f226d0dc80f https://doi.org/10.1002/hlca.19950780212 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........3178d5b2f521786187774f226d0dc80f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222675 0018019X |
|---|---|
| DOI: | 10.1002/hlca.19950780212 |