التفاصيل البيبلوغرافية
العنوان:
Potent imidazole angiotensinII antagonists: acyl sulfonamides and acyl sulfamides as tetrazole replacements
المؤلفون:
Gloria J. Zingaro , William J. Greenlee , Tsing-Bau Chen , Kristie A. Faust , Pancras C. Wong , Ruth R. Wexler , Victor J. Lotti , Peter K. S. Siegl , Raymond S.L. Chang , Prasun K. Chakravarty , Elizabeth M. Naylor , Salah D. Kivlighn , Colleen A. Costello , Arthur A. Patchett , David J. Carini
المصدر:
Bioorganic & Medicinal Chemistry Letters . 4:69-74
بيانات النشر:
Elsevier BV, 1994.
سنة النشر:
1994
مصطلحات موضوعية:
chemistry.chemical_classification , Stereochemistry , Organic Chemistry , Clinical Biochemistry , Pharmaceutical Science , Biochemistry , Angiotensin II , In vitro , Sulfonamide , chemistry.chemical_compound , chemistry , In vivo , Biological property , Drug Discovery , cardiovascular system , Molecular Medicine , Imidazole , lipids (amino acids, peptides, and proteins) , Tetrazole , Molecular Biology , hormones, hormone substitutes, and hormone antagonists , circulatory and respiratory physiology , Binding affinities
الوصف:
Acyl sulfonamides and acyl sulfamides were synthesized and their in vitro and in vivo biological properties evaluated. AT1 binding affinities for these potent AII antagonists were similar to their tetrazole analogs. An enhancement in AT2 potencies was observed, particularly with acyl sulfonamides or sulfamides bearing hydrophobic substituents.
تدمد:
0960-894X
DOI:
10.1016/s0960-894x(01)81124-0
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f1bd5f8936506268fac7d94f6e8eea2 https://doi.org/10.1016/s0960-894x (01)81124-0
Rights:
CLOSED
رقم الانضمام:
edsair.doi...........2f1bd5f8936506268fac7d94f6e8eea2
قاعدة البيانات:
OpenAIRE