AB0735 POLYMORPHISMS OF GENES CD14, C-REACTIVE PROTEIN, FIBRINOGEN BETA CHAIN, ASSOCIATED WITH THE DEVELOPMENT OF KAWASAKI DISEASE AND CORONARY ARTERY ANEURYSMS IN CHILDREN FROM CENTRAL RUSSIA
| العنوان: | AB0735 POLYMORPHISMS OF GENES CD14, C-REACTIVE PROTEIN, FIBRINOGEN BETA CHAIN, ASSOCIATED WITH THE DEVELOPMENT OF KAWASAKI DISEASE AND CORONARY ARTERY ANEURYSMS IN CHILDREN FROM CENTRAL RUSSIA |
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| المؤلفون: | Seda Kh Kurbanova, E. Zheludova, A. Glazyrina, Y. Novikova, E. Tarasenko, M.G. Kantemirova, Dmitry Yu Ovsyannikov, M. Azova |
| المصدر: | Annals of the Rheumatic Diseases. 80:1397.2-1397 |
| بيانات النشر: | BMJ, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | biology, business.industry, Fibrinogen beta chain, CD14, Immunology, C-reactive protein, medicine.disease, General Biochemistry, Genetics and Molecular Biology, medicine.anatomical_structure, Rheumatology, medicine, biology.protein, Immunology and Allergy, Kawasaki disease, business, Gene, Artery |
| الوصف: | Background:Kawasaki disease (KD) is a multifactorial disease with a genetic predisposition, systemic vasculitis complicated by the formation of coronary artery aneurysms (CAA). Its pathogenesis is based on immune inflammation with an increase in the concentration of pro-inflammatory cytokines, the level of C-reactive protein (CRP), and coagulation disorder.Objectives:to search for polymorphisms of genes cluster of differentiation CD14, CRP, fibrinogen beta chain (FGB), associated with the KD development and a predisposition to the CAA formation among patients with KD living in Moscow and the Moscow region.Methods:genotyping for gene polymorphisms CD14 –159 C>T (rs2569190), CRP 3872 C>T (rs1205), FGB – 455 G>A (rs1800790) by PCR in 31 children 1 month – 10 years old (median age 19 months [9,0; 38,5]) with KD, among them, in 10 patients the disease was complicated by CAA formation according to echocardiography, and 30 children of the control group.Results:Three out of six investigated SNPs showed statistically significant difference in genotype and allele distribution: СRP C3872T, CD14 C159T and FGB G455A. CRP gene polymorphism: in patients with KD significantly less frequent is homozygous type TT (RR 0,22, 95% CI: 0,05–0,91, p=0,0168).CD14 gene polymorphism: in control group heterozygous genotype CT is predominant, (RR 0,58, 95% CI: 0,4–0,83, p=0,0017) among patients with KD homozygous genotypes CC and TT are predominant. (RR 3,61, 95% CI: 1,14–11,49, p=0,0057).FGB gene polymorphism: genotype GA is predominant in control group (RR 0,48, 95% CI: 0,26–0,9, p=0,0149). In patients with KD significantly less frequent is homozygous type GG (RR 1,69, 95% CI: 1,03–2,8, p=0,0297).We didn’t find any significant difference in genotype and allele distribution in KD patients with and without CA lesions.Conclusion:statistically significant differences (pT, CRP 3872 C>T and FGB –455 G>A genes among patients with KD and children of the control group; when comparing the results of KD patients with CAA and the control group, statistically significant differences (pT. It can be assumed that these polymorphisms are associated with the development of KD and CAA in these patients.Disclosure of Interests:None declared |
| تدمد: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2021-eular.2807 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2e78d9c36fc843a9ed40a068bd01bf11 https://doi.org/10.1136/annrheumdis-2021-eular.2807 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........2e78d9c36fc843a9ed40a068bd01bf11 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682060 00034967 |
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| DOI: | 10.1136/annrheumdis-2021-eular.2807 |