Immunoadsorption of sensitized kidney transplant candidates immediately prior to surgery

التفاصيل البيبلوغرافية
العنوان: Immunoadsorption of sensitized kidney transplant candidates immediately prior to surgery
المؤلفون: D Barz, Gero Korten, H Nizze, R Schmidt, Heiko Hickstein, R. Bast
المصدر: Clinical Transplantation. 16:97-101
بيانات النشر: Wiley, 2002.
سنة النشر: 2002
مصطلحات موضوعية: Transplantation, Kidney, Creatinine, medicine.medical_specialty, Blood transfusion, business.industry, medicine.medical_treatment, medicine.disease, Preoperative care, Surgery, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, medicine, business, Complication, Immunoadsorption, Kidney disease
الوصف: Patients with anti-human leucocyte antigen (HLA) antibodies from previous transplantation, blood transfusion are highly sensitized and at risk to hyperacute renal graft loss. As these antibodies are identified to be of pathogenic importance, an effective removal may allow successful transplantation. Six 'high risk patients' [panel-reactive antibodies (PRA) >30% or retransplanted patients with an acutely rejected first graft within 6 months from surgery] were treated by protein A immunoadsorption (IA) immediately prior to transplantation. We treated the calculated plasma volume one to three times prior to surgery: mean 4600 mL (range 2100-10 200 mL). After transplantation we repeated the sessions according to antibody (Ab) recurrence, graft function and signs of rejection. The panel reactive Ab were reduced from mean 65% pre-IA (range 35-85) to lowest 15% (range 0-55). After the course they reappeared to 30% (range 0-90). Five of the six patients had no clinical signs of vascular rejection. At a follow-up of mean 54 months (+/-14) four grafts still function with a mean serum creatinine of 172 micromol/L (+/-57). Protein A IA is a safe and effective adjunct in the treatment of highly sensitized patients awaiting renal transplantation. The treatment immediately prior to operation can prevent hyperacute rejection and increases the graft survival in these patients.
تدمد: 0902-0063
DOI: 10.1034/j.1399-0012.2002.1o047.x
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2e4caf8c12e4a9bf68722013b2f8f10d
https://doi.org/10.1034/j.1399-0012.2002.1o047.x
Rights: CLOSED
رقم الانضمام: edsair.doi...........2e4caf8c12e4a9bf68722013b2f8f10d
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09020063
DOI:10.1034/j.1399-0012.2002.1o047.x