Objective: To contribute to the explanation of the etiology of enuresis, which is quite prevalent, by investigating its relationship with urine pH and density. Methods: A total of 45558 children were included in the study. Based on screening results, 44201 children without enuresis were assigned to Group 1 and 1357 children with enuresis to Group 2. Complete urinalysis results of all children who had been identified were scanned and values of urine pH and density were obtained. Intergroup differences with regard to urine pH and density were analyzed using Student’s t-test. A p value of