Synthesis of Internal Alkynes through an Effective Tandem Elimination–Hydrodebromination–Cross-Coupling of gem-Dibromoalkenes with Halobenzenes
| العنوان: | Synthesis of Internal Alkynes through an Effective Tandem Elimination–Hydrodebromination–Cross-Coupling of gem-Dibromoalkenes with Halobenzenes |
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| المؤلفون: | Zinan Kang, Guo-bing Yan, Ning Zhong, Yuan Ji, Ming Zhao |
| المصدر: | Synlett. 29:209-214 |
| بيانات النشر: | Georg Thieme Verlag KG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Coupling, chemistry.chemical_classification, Tandem, 010405 organic chemistry, Organic Chemistry, Sonogashira coupling, Alkyne, Halide, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Chemical synthesis, 0104 chemical sciences, Functional importance, chemistry, Halobenzene, Organic chemistry |
| الوصف: | Carbon–carbon couplings are among the most important strategies for constructing functional molecules in organic synthetic chemistry, and cheap, diverse, and readily available coupling partners are crucial to these diverse reactions. In this contribution, we report the first palladium-catalyzed C–C cross-coupling reaction of two kinds of organic halide, a gem-dibromoalkene and a halobenzene, as the starting materials. Terminal alkynes were generated in situ through a tandem elimination–hydrodebromination process, and the internal alkyne final products were synthesized in one pot. The reaction proceeded under simple, facile, and classic copper-free Sonogashira coupling reaction conditions in good to excellent yields. |
| تدمد: | 1437-2096 0936-5214 |
| DOI: | 10.1055/s-0036-1590907 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2cce604055b8d0a99dbfe5aabd0cbad6 https://doi.org/10.1055/s-0036-1590907 |
| رقم الانضمام: | edsair.doi...........2cce604055b8d0a99dbfe5aabd0cbad6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14372096 09365214 |
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| DOI: | 10.1055/s-0036-1590907 |